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Synfacts 2008(12): 1336-1336
DOI: 10.1055/s-0028-1083576
DOI: 10.1055/s-0028-1083576
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Imidazolium-Tagged Hydroxyproline
M. Lombardo*, F. Pasi, S. Easwar, C. Trombini*
Università degli Studi di Bologna and Consorzio Interuniversitario Nazionale La Chimica per l’ Ambiente, Marghera, Italy
Further Information
Publication History
Publication Date:
20 November 2008 (online)
![](https://www.thieme-connect.de/media/synfacts/200812/lookinside/thumbnails/10.1055-s-0028-1083576-1.jpg)
Significance
trans-4-Hydroxy-l-proline tagged with an imidazolium moiety efficiently catalyzes the direct asymmetric cross-aldol reaction under aqueous biphasic conditions. Compared to the reaction in ionic liquids, better results in terms of catalytic activity and stereochemical performance are achieved. Furthermore, facile separation of the catalyst and recycling for five times without considerable loss of yield and stereoselectivity is shown.