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Synfacts 2008(12): 1332-1332
DOI: 10.1055/s-0028-1083580
DOI: 10.1055/s-0028-1083580
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Pyridinium Salts as New Organocatalysts for Acetalizations
B. Procuranti, S. J. Connon*
University of Dublin, Ireland
Further Information
Publication History
Publication Date:
20 November 2008 (online)
Significance
An efficient pyridinium-salt-1-catalyzed acetalization of aldehydes and ketones has been described. Among different pyridinium salts, catalyst 1 proved to be the most efficient species, with partially remarkable short reaction times (1 min to 48 h) and low catalyst loadings (0.1-10 mol%). The catalyst is proposed to form alcohol adducts, along with HBr acting as Brønsted acid catalyst.