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Synfacts 2008(12): 1333-1333  
DOI: 10.1055/s-0028-1083582
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

A New Bifunctional Catalyst: The Direct Amination of α-Cyanoketones

Contributor(s): Benjamin List, Kristina Zumbansen
S. M. Kim, J. H. Lee, D. Y. Kim*
Soonchunhyang University, Chungnam, Korea
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Publication History

Publication Date:
20 November 2008 (online)

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Significance

A direct α-amination of cyclic and acyclic α-cyanoketones catalyzed by bifunctional organocatalyst 1 with azodicarboxylates as electrophilic nitrogen source is reported. The catalyst amount can be reduced up to 1 mol% without any loss of enantioselectivity.