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Synfacts 2008(12): 1316-1316
DOI: 10.1055/s-0028-1083586
DOI: 10.1055/s-0028-1083586
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Sonogashira Couplings of Aryl Bromides at Room Temperature in Water
B. H. Lipshutz*, D. W. Chung, B. Rich
University of California, Santa Barbara, USA
Further Information
Publication History
Publication Date:
20 November 2008 (online)
Significance
Terminal alkynes react with aryl bromides in water at ambient temperature in the presence of an amphiphilic nanomicelle-forming reagent PTS. The development of new processes using pure water as a solvent is quite important for the chemical industry, since they allow decreasing the amount of the produced wastes as well as the manufacturing costs of products.