Coupling of Cyclopropyl- and Cyclobutyl-trifluoroborates
with Aryl Chlorides

G. A. Molander; P. E. Gormisky

doi:10.1055/s-0028-1083587

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Synfacts 2008(12): 1318-1318
DOI: 10.1055/s-0028-1083587

Metal-Mediated Synthesis

Coupling of Cyclopropyl- and Cyclobutyl-trifluoroborates with Aryl Chlorides

Contributor(s): Paul Knochel, Andrei Gavryushin
G. A. Molander*, P. E. Gormisky
University of Pennsylvania, Philadelphia, USA

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Publication History

Publication Date:
20 November 2008 (online)

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Significance

Specific steric and electronic properties of cyclopropyl and cyclobutyl groups give interesting opportunities for the creation of new biologically active molecules. This convenient and versatile method protocol uses cycloalkyltrifluoroborates as shelf-stable cycloalkyl nucleophiles, and inexpensive aryl chlorides as coupling partners.