Ru-Catalyzed Selective Redox Isomerization of Propargylic
Alcohols

doi:10.1055/s-0028-1083591

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Synfacts 2008(12): 1322-1322
DOI: 10.1055/s-0028-1083591

Metal-Mediated Synthesis

Ru-Catalyzed Selective Redox Isomerization of Propargylic Alcohols

Contributor(s): Paul Knochel, Andreas J. Wagner
B. M. Trost*, R. C. Livingston
Stanford University, USA

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Publication History

Publication Date:
20 November 2008 (online)

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Significance

The authors report a novel method for performing the isomerization of propargylic alcohols in high yields to selectively provide (E)-enals and enones using a readily available catalyst. A propargylic hydride migration-based mechanism has been suggested in deuterium-labeling experiments.