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Synfacts 2008(12): 1315-1315  
DOI: 10.1055/s-0028-1083594
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Efficient Cross-Coupling Using Pd-Phosphinous Acid Catalysts

Contributor(s): Paul Knochel, Andreas J. Wagner
H. Xu, K. Ekoue-Kovi, C. Wolf*
Georgetown University, Washington, USA
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Publication History

Publication Date:
20 November 2008 (online)

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Significance

In this work, several Pd-posphinous acids have been prepared and used as catalysts for the cross-coupling of aryl or acyl halides with organozinc compounds. Even sterically hindered substrates lead to excellent results. Also, acyl halides were converted into the corresponding ketones in up to 98% yield.