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Synfacts 2008(12): 1245-1245  
DOI: 10.1055/s-0028-1087282
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of 35-Deoxy Amphotericin B Methyl Ester

Contributor(s): Philip Kocienski, Arndt W. Schmidt
A. M. Szpilman, J. M. Manthorpe, E. M. Carreira*
ETH ZÜrich, Switzerland
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Publikationsdatum:
20. November 2008 (online)

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Significance

Amphotericin B induces loss of electrochemical membrane potential by formation of ion channels. The exact mechanism of action including the necessity of the 35-hydroxy group has been debated. A scalable, modular access to the 35-deoxy derivative provides sufficient material for biological screening. Accompanying paper: E. M. Carreira and co-workers Angew. Chem. Int. Ed. 2008, 47, 4335.