Download PDF
Synfacts 2009(1): 0074-0074  
DOI: 10.1055/s-0028-1087401
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Cobalt-Catalyzed Asymmetric Cyclopropanation

Contributor(s): Mark Lautens, Jane Panteleev
S. Zhu, J. A. Perman, X. P. Zhang*
University of South Florida, Tampa, USA
Further Information

Publication History

Publication Date:
18 December 2008 (online)

    Permissions and Reprints

Significance

In light of ongoing interest in the synthesis of chiral cyclopropanes, the authors report an application of a cobalt(II)-porphyrinoid complex in cyclopropanation with acceptor/acceptor-substituted carbenoids. A generous scope is noted with good yields and high diastereo- and enantio­selectivities.

Review: H. M. L. Davies, R. E. J. Beckwith Chem. Rev. 2003, 103, 2861-2904.