Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2009(2): 0176-0176
DOI: 10.1055/s-0028-1087567
DOI: 10.1055/s-0028-1087567
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Copper(I)-Catalyzed Hetero-Diels-Alder Reaction of Ketones
I-H. Chen, K. Oisaki, M. Kanai*, M. Shibasaki*
The University of Tokyo, Japan
Further Information
Publication History
Publication Date:
22 January 2009 (online)
Significance
This paper describes the hetero-Diels-Alder reaction between Danishefsky-type dienes and ketones to generate dihydropyranone products, which is a significant extension of the previously developed copper-catalyzed aldol reactions. By using the chiral Walphos ligands, the first catalytic enantioselective hetero-Diels-Alder reaction of simple ketones is realized.