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Synfacts 2009(5): 0549-0549  
DOI: 10.1055/s-0028-1088189
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Unsymmetric Ureas via Palladium-Catalyzed Amidation

Contributor(s): Paul Knochel, Andreas J. Wagner
B. J. Kotecki*, D. P. Fernando, A. R. Haight, K. A. Lukin
Abbott Laboratories, Chicago, USA
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Publication History

Publication Date:
22 April 2009 (online)

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Significance

Bippyphos, a novel nonproprietary bipyrazole ligand, in combination with Pd2(dba)3 is demonstrated to be an efficient catalyst for the amidation of aryl and N-heterocyclic chlorides and bromides using monosubstituted phenyl, benzyl or alkyl ureas. The reaction proceeds in moderate to very good yields and tolerates a variety of functional groups using potassium phosphate as a mild base.