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Synfacts 2009(5): 0507-0507  
DOI: 10.1055/s-0029-1216566
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart ˙ New York

Bringing Porphyrine into the NIR Region

Contributor(s): Timothy M. Swager, Jose M. Lobez
S. Tokuji, Y. Takahashi, H. Shinmori*, H. Shinokubo*, A. Osuka*
Kyoto University and University of Yamanashi, Kofu, Japan
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Publication History

Publication Date:
22 April 2009 (online)

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Significance

Near infrared (NIR) dyes are used in photodynamic therapy for the generation of singlet oxygen. The family of compounds synthesized (oxopyridochlorins) exhibits absorption bands within the therapeutic window (750-900 nm). Studies of singlet oxygen generation give positive results for compounds 1a and 2a.