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Synfacts 2009(5): 0561-0561  
DOI: 10.1055/s-0029-1216584
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Aldol Reactions Catalyzed by an Activated Primary Amine Catalyst

Contributor(s): Benjamin List, Kristina Zumbansen
C.-S. Da, L.-P. Che, Q.-P. Guo, F.-C. Wu, X. Ma, Y.-N. Jia
Lanzhou University, P. R. of China
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Publication History

Publication Date:
22 April 2009 (online)

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Significance

Da and co-workers report a direct asymmetric aldol reaction using primary amine catalyst 1 and 2,4-dinitrophenol (DNP) as an efficient chiral organocatalytic system. High enantio-selectivities and good to high diastereoselectivities were obtained. Linear ketones and cyclo-­pentanone gave mainly syn products, whereas cyclohexanone gave the anti diastereomer as the major product.