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Synfacts 2009(7): 0782-0782  
DOI: 10.1055/s-0029-1217257
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Ir(I)-Catalyzed sp³ C-H Bond Alkenylation of Amides with Alkynes

Contributor(s): Paul Knochel, Andrei Gavryushin
K. Tsuchikawa, M. Kasagawa, K. Endo, T. Shibata*
Waseda University, Tokyo, Japan
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Publication History

Publication Date:
22 June 2009 (online)

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Ir(I)-Catalyzed sp³ C-H Bond Alkenylation of Amides with AlkynesSynfacts 2009; 2009(10): 1180-1180
DOI: 10.1055/s-0029-1217796

Significance

The direct functionalization of unactivated sp³ C-H bonds has currently attracted a lot of attention. This iridium(I)-catalyzed C-H bond alkenylation allows for a straightforward construction of highly substituted allylic amides. This interesting carbonyl-directed sp³ C-H bond cleavage by iridium(I) leads to new developments in the growing field of C-H activation chemistry.