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Synfacts 2009(7): 0761-0761
DOI: 10.1055/s-0029-1217292
DOI: 10.1055/s-0029-1217292
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Demonstration of Absolute Asymmetric Synthesis
A. Lennartson, S. Olsson, J. Sundberg, M. Håkansson*
University of Gothenburg, Sweden
Further Information
Publication History
Publication Date:
22 June 2009 (online)
Significance
Absolute asymmetric synthesis means to synthesize chiral molecules without any chiral materials such as catalysts, auxiliaries or reagents. The authors demonstrated an absolute asymmetric synthesis with crystallization of one enantiomer of a zinc reagent from its racemic mixture and subsequent reaction with NCS to provide enantiomer-enriched 1-chloroindene in high enantiomeric excess and chemical yield.