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Synfacts 2009(7): 0800-0800  
DOI: 10.1055/s-0029-1217303
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

Aza-Michael Addition Catalyzed by Camphorsulfonyl Hydrazines

Contributor(s): Benjamin List, Kristina Zumbansen
L.-Y Chen, H. He, B.-J. Pei, W.-H. Chan, A. W. M. Lee
Hong Kong Baptist University, P. R. of China
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Publication History

Publication Date:
22 June 2009 (online)

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Significance

Lee and coworker report an enan­tioselective aza-Michael addition catalyzed by sulfonyl hydrazines 1 and TCA as an additive. The addition products were then reduced to the corresponding alcohol. Using aliphatic aldehydes good to moderate yields and enantioselectivities were achieved, whereas aromatic aldehydes were un­reactive under these conditions.