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Synfacts 2009(8): 0874-0874
DOI: 10.1055/s-0029-1217436
DOI: 10.1055/s-0029-1217436
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Lanthanum(III)-Catalyzed Cyclopropanation
D. J. Hardee, T. H. Lambert*
Columbia University, New York, USA
Further Information
Publication History
Publication Date:
23 July 2009 (online)
Significance
A lanthanum(III) triflate catalyzed cyclopropanation protocol involving the methylene transfer from epoxides to olefins is described. The resulting aldehydes and ketones are obtained in good yield and the reactions proceed with high diastereoselectivity. Furthermore, enantioenriched cyclopropanes can be obtained following asymmetric epoxidation and methylene transfer reactions.