Download PDF
Synfacts 2009(10): 1120-1120  
DOI: 10.1055/s-0029-1217848
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Aza-enolate Addition to Imines Catalyzed by Alkaline Earth Metals

Contributor(s): Mark Lautens, David A. Candito
H. Van Nguyen, R. Matsubara, S. Kobayashi*
The University of Tokyo and ERATO Science Technology Agency (JST), Tokyo, Japan
Further Information

Publication History

Publication Date:
22 September 2009 (online)

    Permissions and Reprints

Significance

The authors previously reported the use of sulfonylimidates in base-catalyzed direct additions to imines (J. Am. Chem. Soc. 2008, 130, 1804; Synfacts 2008, 375). In this work the alkaline earth metal catalyzed asymmetric addition of sulfonylimidates to imines is investigated. Alkaline earth metals have received relatively little attention despite the advantages their use can provide, such as low cost, ready availability and low toxicity.