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Synfacts 2009(10): 1068-1068  
DOI: 10.1055/s-0029-1217855
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-Amphidinolide K

Contributor(s): Philip Kocienski, Indu Dager
H. M. Ko, C. W. Lee, H. K. Kwon, H. S. Chung, S. Y. Choi, Y. K. Chung, E. Lee*
Seoul National University, Korea
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Publikationsverlauf

Publikationsdatum:
22. September 2009 (online)

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Significance

(-)-Amphidinolide K shows cytotoxic activity against L1210 (IC50 = 1.65 µg/mL) and KB (IC50 = 2.9 µg/mL) cancer cell lines. A radical cyclization reaction of homopropargylic derivative A and an enyne cross-metathesis reaction of an alkynyl boronate D and an alkene E were the two premiere steps in the total synthesis.