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Synfacts 2009(10): 1067-1067  
DOI: 10.1055/s-0029-1217865
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of ent-Malbrancheamide B

Contributor(s): Philip Kocienski, Zofia Komsta
F. Frebault, N. S. Simpkins*, A. Fenwick
The University of Birmingham and Pfizer Central Research, Sandwich, UK
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Publication History

Publication Date:
22 September 2009 (online)

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Significance

Malbrancheamide B was extracted from the fungus Malbranchea aurantiaca. A related compound, malbrancheamide A, is a calmo­diulin inhibitor. A focal step of this very concise synthesis is the TMSOTf-promoted cyclization of F proceeding through an acyliminium cascade cyclization.