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Synfacts 2009(10): 1062-1062
DOI: 10.1055/s-0029-1217869
DOI: 10.1055/s-0029-1217869
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Valerenic Acid
J. Ramharter, J. Mulzer*
University of Vienna, Austria
Further Information
Publication History
Publication Date:
22 September 2009 (online)
Significance
Valerenic acid was extracted from the roots of Valeriana officinalis. It is a selective modulator of GABAA receptor subtypes and therefore a potential drug against various central nervous system dysfunctions. The focal step of this short and high-yielding synthesis is an intramolecular, metal-coordinated Diels-Alder reaction (B → D).