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Synfacts 2009(10): 1176-1176  
DOI: 10.1055/s-0029-1217872
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Deprotection of the N-Nosyl Group with a Thiol Resin

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Chung Keun Jin
R. De Marco, M. L. Di Gioia, A. Leggio, A. Liguori*, M. C. Viscomi
Università della Calabria, Arcavacata di Rende, Italy
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Publication History

Publication Date:
22 September 2009 (online)

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Significance

Polymer-supported thiol 5 was prepared and used in the cleavage of N-nosyl groups from protected α-amino acids. Thus, the polymer-supported thiol 5 was prepared from 4,4′-dimeth-oxytrityl chloride 1 and Wang resin (three steps). Deprotection of N-nosyl-α-amino acids 6 was ­carried out with 5 and DBU to give the corresponding amines 7 .