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Synfacts 2009(10): 1177-1177  
DOI: 10.1055/s-0029-1217875
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Kumada-Tamao Coupling by Using an Immobilized Nickel Catalyst

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Maki Minakawa
X. Chen, L. Wang*, J. Liu
Huaibei Coal Teachers College, Anhui and Shanghai Institute of Organic Chemistry, P. R. of China
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Publication History

Publication Date:
22 September 2009 (online)

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Significance

Kumada-Tamao cross-coupling of aryl halides with aryl Grignard reagents using an organic-inorganic hybrid material immobilized nickel catalyst was described. The immobilized nickel catalyst (silica-APTS-Pyr-Ni) was readily prepared in five steps and subsequently used for the Kumada-Tamao reaction. Thus, the cross-coupling reaction of a variety of aryl bromides and aryl chlorides with phenylmagnesium bromide was catalyzed by silica-APTS-Pyr-Ni to give the corresponding biaryls.