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Synfacts 2009(11): 1188-1188  
DOI: 10.1055/s-0029-1218035
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of a Selective PPARγ Modulator

Contributor(s): Philip Kocienski
P. E. Maligres*, G. R. Humphrey*, J.-F. Marcoux, M. C. Hillier, D. Zhao, S. Krska, E. J. J. Grabowski
Merck & Co., Rahway, USA
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Publication History

Publication Date:
22 October 2009 (online)

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Significance

The target molecule selectively modulates the γ peroxisome proliferator-activated receptor (PPAR) and was a candidate as an anti­diabetic agent. The synthesis depicted delivered >3 kg of the drug in 50% overall yield and with >99.5% ee.