Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2009(11): 1299-1299
DOI: 10.1055/s-0029-1218066
DOI: 10.1055/s-0029-1218066
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Aldol Reaction with Polymer-Supported Proline Derivatives
T. E. Kristensen, K. Vestli, K. A. Fredriksen, F. K. Hansen, T. Hansen*
University of Oslo, Norway
Further Information
Publication History
Publication Date:
22 October 2009 (online)
Significance
Proline-derived polymer beads A were prepared from trans-4-hydroxy-l-proline via suspension copolymerization with styrene and divinylbenzene in polyvinyl alcohol (PVA) (eq. 1). The proline beads A catalyzed the aldol reaction of 4-nitrobenzaldehyde with cyclohexanone to give the corresponding aldol adduct in up to 91% yield with up to 97% anti selectivity and 98% ee (eq. 2).