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Synfacts 2009(11): 1299-1299  
DOI: 10.1055/s-0029-1218066
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Aldol Reaction with Polymer-Supported Proline Derivatives

Contributor(s): Yasuhiro Uozumi, Takao Osako
T. E. Kristensen, K. Vestli, K. A. Fredriksen, F. K. Hansen, T. Hansen*
University of Oslo, Norway
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Publikationsverlauf

Publikationsdatum:
22. Oktober 2009 (online)

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Significance

Proline-derived polymer beads A were prepared from trans-4-hydroxy-l-proline via suspension copolymerization with styrene and divinylbenzene in polyvinyl alcohol (PVA) (eq. 1). The proline beads A catalyzed the aldol reaction of 4-nitrobenzaldehyde with cyclohexanone to give the corresponding aldol adduct in up to 91% yield with up to 97% anti selectivity and 98% ee (eq. 2).