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Synfacts 2009(12): 1396-1396
DOI: 10.1055/s-0029-1218175
DOI: 10.1055/s-0029-1218175
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Fe-Catalyzed 1,4-Hydroboration of 1,3-Dienes
J. Y. Wu, B. Moreau, T. Ritter*
Harvard University, Cambridge, USA
Further Information
Publication History
Publication Date:
20 November 2009 (online)
Significance
In this first report of an iron-catalyzed hydroboration of olefinic substrates, pinacolborane is regioselectively added to a variety of 1,3-dienes in the presence of catalytic amounts of FeCl2. Amongst various ligands tested for this reaction, iminopyridine ligands have shown to be highly effective, affording the borylated alkene products in high yields and excellent E/Z-selectivity.