Synthesis of Aldimines from Alcohols and Amines with Ru(OH)x/TiO2

J. W. Kim; J. He; K. Yamaguchi; N. Mizuno

doi:10.1055/s-0029-1218201

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Synfacts 2009(12): 1421-1421
DOI: 10.1055/s-0029-1218201

Polymer-Supported Synthesis

Synthesis of Aldimines from Alcohols and Amines with Ru(OH)_x/TiO₂

Contributor(s): Yasuhiro Uozumi, Go Hamasaka
J. W. Kim, J. He, K. Yamaguchi, N. Mizuno*
The University of Tokyo and Japan Science and Technology Agency, Kawaguchi, Japan

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Publication History

Publication Date:
20 November 2009 (online)

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Significance

TiO₂-supported ruthenium hydroxides (Ru(OH)_x/TiO₂) catalyzed the oxidative condensation of primary alcohols 1 with primary amines 2 under 1 atm of O₂ to give the corresponding aldimines 3 in 62-98% yield (11 examples). The catalyst was recovered by simple filtration and reused without significant loss of catalytic performance for the formation of 3a (reuse: 94%).