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Synfacts 2009(12): 1351-1351
DOI: 10.1055/s-0029-1218245
DOI: 10.1055/s-0029-1218245
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Iridium-Catalyzed N-Allylation of Indoles
L. M. Stanley, J. F. Hartwig*
University of Illinois Urbana-Champaign, USA
Further Information
Publication History
Publication Date:
20 November 2009 (online)
Significance
The iridium-catalyzed N-allylation of indoles is described. The products are obtained in good yield and with high regio- and enantioselectivity. This protocol is an extension on previous research involving the N-allylation of benzimidazoles, imidazoles, and purines (J. Am. Chem. Soc. 2009, 131, 8971).