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Synfacts 2010(3): 0262-0262  
DOI: 10.1055/s-0029-1219246
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Engerlin A

Contributor(s): Steven V. Ley, Catherine F. Carter
M. Willot, L. Radtke, D. Könning, R. Fröhlich, V. H. Gessner, C. Strohmann, M. Christmann*
TU Dortmund and Universität Münster, Germany
Further Information

Publication History

Publication Date:
18 February 2010 (online)

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Corrected by:

Synthesis of Englerin ASynfacts 2010; 2010(04): 0500-0500
DOI: 10.1055/s-0029-1219631

Significance

Engerlin A inhibits the growth of ­renal cancer cell lines with GI50 values from 1-87 nM. The total synthesis is achieved in 15 steps with an overall yield of 11%.