Synthesis of (-)-Galanthamine and (±)-Codeine

P. Magnus; N. Sane; B. P. Fauber; V. Lynch

doi:10.1055/s-0029-1219251

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Synfacts 2010(3): 0255-0255
DOI: 10.1055/s-0029-1219251

Synthesis of Natural Products and Potential Drugs

Synthesis of (-)-Galanthamine and (±)-Codeine

Contributor(s): Steven V. Ley, Matthew O’Brien
P. Magnus*, N. Sane, B. P. Fauber, V. Lynch
University of Texas at Austin, USA

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Publication History

Publication Date:
18 February 2010 (online)

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Significance

The amaryllidaceae alkaloid (-)-galanthamine is a potent inhibitor of acetylcholinesterase and has been used in the early treatment of Alzheimer’s disease. As such, it has been a popular target for total synthesis projects.