Silver(I)-Catalyzed Decarboxylation of Aromatic Carboxylic
Acids

doi:10.1055/s-0029-1219302

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Synfacts 2010(3): 0338-0338
DOI: 10.1055/s-0029-1219302

Metal-Mediated Synthesis

Silver(I)-Catalyzed Decarboxylation of Aromatic Carboxylic Acids

Contributor(s): Paul Knochel, Andrei Gavryushin
P. Lu, C. Sanchez, J. Cornella, I. Larrosa*
Queen Mary University of London, UK

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Publication History

Publication Date:
18 February 2010 (online)

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Significance

Known methods of decarboxylation of aromatic carboxylic acids use very high temperatures (170-200 ˚C) and high-boiling solvents like quinoline. This work describes a convenient, widely applicable procedure for silver(I)-catalyzed decarboxylation of various benzoic and heteroaromatic carboxylic acids under relatively mild conditions (DMSO, 120 ˚C).