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Synfacts 2010(3): 0360-0360  
DOI: 10.1055/s-0029-1219413
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

A Magnetic Multi-Purpose Organocatalyst

Contributor(s): Benjamin List, Lars Ratjen
V. Polshettiwar*, R. S. Varma*
King Abdullah University of Science and Technology, Thuwal, Kingdom of Saudi Arabia and National Risk Management Research Laboratory, Cincinnati, USA
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Publikationsverlauf

Publikationsdatum:
18. Februar 2010 (online)

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Significance

The straightforward synthesis of magnetic nanoparticle-supported glutathione 1 and its use as ”organocatalyst" is reported. The immobilized and reusable catalyst 1 proved to be active in a number of different reactions. The Paal-Knorr pyrrole synthesis, aza-Michael reaction, and pyrazole synthesis were carried out in water as ­reaction medium under microwave irradiation, providing the reaction products in high yields after short reaction times.