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Synfacts 2010(3): 0282-0282  
DOI: 10.1055/s-0029-1219425
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart ˙ New York

l-Proline-Catalyzed Synthesis of Highly Substituted 1,4-Dihydropyridines

Contributor(s): Victor Snieckus, Johnathan Board
H. Jiang*, R. Mai, H. Cao, Q. Zhu, X. Liu
South China University of Technology, Guangzhou, P. R. of China
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Publication History

Publication Date:
18 February 2010 (online)

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Significance

Reported is the l-proline-catalyzed multicomponent synthesis of non-symmetric dihydropyridines. The reaction appears to be remarkably unaffected by electronic or steric considerations, as evidenced by only modest variations in yield when moving among different substrates. However, when 4-nitrobenzaldehyde was used the reaction temperature required an increase of the temperature to 50 ˚C and the time to 24 h.