Palladium-Catalyzed Copper-Free Wacker Oxidation of Internal
Olefins

T. Mitsudome; K. Mizumoto; T. Mizugaki; K. Jitsukawa; K. Kaneda

doi:10.1055/s-0029-1219591

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Synfacts 2010(4): 0468-0468
DOI: 10.1055/s-0029-1219591

Metal-Mediated Synthesis

Palladium-Catalyzed Copper-Free Wacker Oxidation of Internal Olefins

Contributor(s): Paul Knochel, Andreas J. Wagner
T. Mitsudome, K. Mizumoto, T. Mizugaki, K. Jitsukawa, K. Kaneda*
Osaka University, Japan

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Publication History

Publication Date:
22 March 2010 (online)

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Significance

A variation of the Wacker oxidation is disclosed by which a PdCl₂/DMA catalyst system can be successfully used for the oxidation of various internal olefins to carbonyl compounds. The methodology is very simple to perform and the oxidation proceeds efficiently without isomerization of the olefins.