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Synfacts 2010(5): 0510-0510  
DOI: 10.1055/s-0029-1219708
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of ent-Hyperforin

Contributor(s): Steven V. Ley, Matthew O’Brien
Y. Shimizu, S.-L. Shi, H. Usuda, M. Kanai, M. Shibasaki*
The University of Tokyo, Japan
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Publikationsdatum:
22. April 2010 (online)

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Significance

Hyperforin is the main active component of the herbal antidepressant St. John’s wort (Hypericum perforatum). The complex and synthetically challenging molecular architecture contains three quaternary centers, two of which are contiguous.