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Synfacts 2010(6): 0703-0703
DOI: 10.1055/s-0029-1219772
DOI: 10.1055/s-0029-1219772
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Palladium-Catalyzed Direct Cyanation of Indoles with K4[Fe(CN)6]
G. Yan, C. Kuang, Y. Zhang, J. Wang*
Beijing National Laboratory for Molecular Sciences, Peking University, Beijing and Tongji University, Shanghai, P. R. of China
Further Information
Publication History
Publication Date:
20 May 2010 (online)
Significance
Direct cyanation of indole derivatives has been achieved with nontoxic K4[Fe(CN)6] as cyanating agent. This selective cyanation is carried out with a palladium-catalyzed C-H bond activation using a Wacker-type regeneration of the catalyst.