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Synfacts 2010(6): 0668-0668
DOI: 10.1055/s-0029-1219969
DOI: 10.1055/s-0029-1219969
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Asymmetric Ullmann Coupling of Biaryl Dials Catalyzed by Nickel
W.-W. Chen, Q. Zhao, M.-H. Xu*, G.-Q. Lin*
Shanghai Institute of Organic Chemistry and Shanghai Institute of Materia Medica, P. R. of China
Further Information
Publication History
Publication Date:
20 May 2010 (online)
![](https://www.thieme-connect.de/media/synfacts/201006/lookinside/thumbnails/10.1055-s-0029-1219969-1.jpg)
Significance
Axially chiral biaryl moieties are common in natural products. The authors developed the first nickel-catalyzed asymmetric Ullmann coupling for substituted aryl halides to yield axially chiral biaryls, and applied this method to the formal synthesis of the natural product (+)-isoschizandrin.