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Synfacts 2010(8): 0863-0863  
DOI: 10.1055/s-0030-1257770
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (+)-Complanadine A

Contributor(s): Steven V. Ley, Kimberley A. Roper
C. Yuan, C.-T. Chang, A. Axelrod, D. Siegel*
The University of Texas at Austin, USA
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Publication History

Publication Date:
22 July 2010 (online)

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Significance

(+)-Complanadine A, a lycopodium alkaloid, has been found to induce secretion of neurotrophic factors promoting cell differentiation in PC-12 cells. This synthesis utilizes the pseudosymmetry of the molecule where two [2+2+2] ­cycloadditions are used to form the pyridine rings.