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Synfacts 2010(8): 0911-0911  
DOI: 10.1055/s-0030-1257783
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Selective Domino Synthesis of Heterocycles through Cooperative Catalysis

Contributor(s): Mark Lautens, Jane Panteleev
C. Wang, Z.-Y. Han, H.-W. Luo, L.-Z. Gong*
University of Science and Technology of China, Hefei, P. R. of China
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Publication History

Publication Date:
22 July 2010 (online)

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Significance

The authors describe a domino synthesis of julolidine derivatives 2. This protocol presents another example in the relatively new field of cooperative catalysis, where both metal and organocatalysts affect a transformation (see Review below). The products are obtained in acceptable yields and high enantioselectivity with variable diastereoselectivities.

Review: Z. Shao, H. Zhang Chem. Soc. Rev. 2009, 38, 2745-2755.