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Synfacts 2010(8): 0964-0964  
DOI: 10.1055/s-0030-1257789
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Silica-Based S-Sulfonic Acid for the Strecker Synthesis

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Chung Keun Jin
K. Niknam*, D. Saberi, M. N. Sefat
Persian Gulf University, Bushehr, Iran
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Publication History

Publication Date:
22 July 2010 (online)

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Significance

Silica-bound S-sulfonic acid catalyst (SBSSA) 2 was prepared from 3-mercaptopropylsilica 1 and chlorosulfonic acid. The one-port condensation of benzaldehyde, aniline, and trimethylsilyl cyanide (TMSCN) was performed with SBSSA in ethanol to afford the α-amino nitrile 5a in 94% yield.