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Synfacts 2010(8): 0943-0943  
DOI: 10.1055/s-0030-1257802
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

Michael Addition of Aldehydes to 2-Amino-1-nitroethenes

Contributor(s): Benjamin List, Ji-Woong Lee
S. Zhu, S. Yu, Y. Wang, D. Ma*
Shanghai Institute of Organic Chemistry and Fudan University, Shanghai, P. R. of China
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Publication History

Publication Date:
22 July 2010 (online)

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Significance

The authors demonstrate the asymmetric Michael addition of aldehydes to 2-amino-1-nitroethenes 4a to afford valuable ­synthons 5 or 7 for 1,2-diamines and 3-amino­pyrrolidines. The obtained syn-adduct ent- 5a could be successfully transformed to (-)-osel­tamivir in four steps.