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Synfacts 2010(11): 1272-1272  
DOI: 10.1055/s-0030-1258748
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

NHC Copper Catalyzed Enantioselective Conjugate Addition

Contributor(s): Hisashi Yamamoto, Jiajing Tan
J. M. O’Brien, K.-s. Lee, A. H. Hoveyda*
Boston College, Chestnut Hill, USA
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Publication History

Publication Date:
21 October 2010 (online)

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Significance

The direct boronate conjugate addition to unsaturated carboxylic esters, ketones, and thioesters is realized by a NHC copper(I) complex, derived from an easily prepared C 1-symmetric imidazolinium salt, to prepare β-boryl carbonyl type products in excellent yields and enantio­selectivities.