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Synfacts 2010(11): 1308-1308  
DOI: 10.1055/s-0030-1258788
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

Organocatalytic Intramolecular 1,5-Hydride Transfer-Ring-Closure Cascade

Contributor(s): Benjamin List, Ilija Čorić
Y. K. Kang, S. M. Kim, D. Y. Kim*
Soonchunhyang University, Asan , Korea
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Publication History

Publication Date:
21 October 2010 (online)

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Significance

An organocatalytic enantioselective intramolecular redox reaction, consisting of a 1,5-hydride transfer followed by 6-endo cyclization has been developed. Secondary amines 1 were indentified as efficient catalysts for the redox cyclization of cinnamaldehyde derivatives 2 to give tetrahydroquinolines 3 with high enantioselectivity in moderate yields.