Synthesis of ACT-178882 (MK-1597)

O. Bezençon et al.

doi:10.1055/s-0030-1258974

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Synfacts 2011(1): 0012-0012
DOI: 10.1055/s-0030-1258974

Synthesis of Natural Products and Potential Drugs

Synthesis of ACT-178882 (MK-1597)

Contributor(s): Philip Kocienski
O. Bezençon et al.*
Actelion Pharmaceuticals, Allschwill, Switzerland

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Publication History

Publication Date:
21 December 2010 (online)

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Significance

The rennin-angiotensin-aldosterone system (RAAS) regulates arterial blood pressure in humans, and plays a crucial role in cardiovascular, renal, and other metabolic diseases. ACT-178882 (MK-1597) is a renin inhibitor with a suitable profile for development.