Selective C4 Alkylation of Pyridines Using Nickel/Lewis
Acid Catalysis

Y. Nakao; Y. Yamada; N. Kashihara; T. Hiyama

doi:10.1055/s-0030-1259113

RSS-Feed abonnieren

Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.

https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml

Teilen / Bookmarken

Facebook X Linkedin Weibo

PDF herunterladen

Synfacts 2011(1): 0080-0080
DOI: 10.1055/s-0030-1259113

Metal-Mediated Synthesis

Selective C4 Alkylation of Pyridines Using Nickel/Lewis Acid Catalysis

Contributor(s): Paul Knochel, Tobias Thaler
Y. Nakao*, Y. Yamada, N. Kashihara, T. Hiyama*
Kyoto University, Japan

Weitere Informationen

Publikationsverlauf

Publikationsdatum:
21. Dezember 2010 (online)

Lizenzen und Reprints

Significance

A direct C4-selective addition of pyridine across alkenes via nickel/Lewis acid cocatalysis has been described. The method proceeds highly regioselectively furnishing the linear 4-alkylpyridines in modest to good yields. Branched 4-alkylpyridines are obtained when styrenes are used.