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Synfacts 2011(1): 0004-0004  
DOI: 10.1055/s-0030-1259127
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-Thespesone

Contributor(s): Steven V. Ley, Philippa B. Cranwell
S. Breyer, K. Effenberger-Neidnicht, R. Schobert*
Universität Bayreuth, Germany
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Publication History

Publication Date:
21 December 2010 (online)

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Significance

(-)-Thespesone was isolated in 1983, but the structure was not elucidated until 2004. Both (-)-thespesone and the unnatural (+)-enantiomer were synthesized, but the naturally occurring isomer was more active against six ­cancer cell lines.