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Synfacts 2011(1): 0009-0009  
DOI: 10.1055/s-0030-1259131
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Cortistatins A, J, K and L

Contributor(s): Steven V. Ley, Kimberley A. Roper
A. N. Flyer, C. Si, A. G. Myers*
Harvard University, Cambridge, USA
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Publication History

Publication Date:
21 December 2010 (online)

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Significance

The cortistatins are structurally ­rearranged steroidal marine alkaloids, which display potency in an anti-angiogenic model, with cortistatin A being the most functionalized and potent. This synthesis combines aspects of previous syntheses to provide rapid access to four of the cortistatin family from a common intermediate L.