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Synfacts 2011(1): 0063-0063  
DOI: 10.1055/s-0030-1259162
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Rhodium-Catalyzed Asymmetric Hydrogenation with a P-Stereogenic Ligand

Contributor(s): Hisashi Yamamoto, Zhi Li
K. Tamura, M. Sugiya, K. Yoshida, A. Yanagisawa, T. Imamoto*
Nippon Chemical industrial Co., Ltd., Tokyo and Chiba University, Japan
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Publication History

Publication Date:
21 December 2010 (online)

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Significance

The authors synthesized a P-­stereogenic bisphosphine ligand and used it in the highly efficient rhodium-catalyzed asymmetric hydrogenation of various olefinic substrates. The achieved catalytic turnover and enantioselectivities are extremely high.