Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2011(1): 0050-0050
DOI: 10.1055/s-0030-1259171
DOI: 10.1055/s-0030-1259171
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Asymmetric Hydrophosphonylation of Ynones
D. Uraguchi, T. Ito, S. Nakamura, T. Ooi*
Nagoya University, Japan
Further Information
Publication History
Publication Date:
21 December 2010 (online)

Significance
Hydrophosphonylation of carbonyl-containing compounds (Pudovik reaction) is a useful way of accessing chiral alkyl phosphonates, but addition to ketones is usually problematic (see Review below). The authors report a hydrophosphonylation of alkynoates utilizing the tetraaminophosphonate catalyst 1. The authors initially reported an application of 1 to an asymmetric addition of phosphonates to aldehydes (J. Am. Chem. Soc. 2009, 131, 3836).
Review: P. Merino, E. Marqués-López, R. P. Herrera Adv. Synth. Catal. 2008, 350, 1195-1208.