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Synfacts 2011(1): 0096-0096  
DOI: 10.1055/s-0030-1259188
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

NHC-Catalyzed Michael Addition to α,β-Unsaturated Aldehydes

Contributor(s): Benjamin List, Ilija Čorić
S. De Sarkar, A. Studer*
Westfälische Wilhelms-Universität Münster, Germany
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Publikationsverlauf

Publikationsdatum:
21. Dezember 2010 (online)

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Significance

Using carbene catalysis and an oxidant, α,β-unsaturated aldehydes can be activated towards Michael addition via a double umpolung process. Various β-dicarbonyl compounds 3 undergo conjugate addition to enals 2 to afford dihydropyranones 4 in good yields.